Evaluation of Protein Backbone Alphabets: Using Predicted Local Structure for Fold Recognition

Date of Submission: 
July 14, 2010
Report Number: 
10-015
Report PDF: 
Abstract: 
Optimally combining available information is one of the key challenges in knowledge-driven prediction techniques. In this study, we evaluate six Phi and Psi-based backbone alphabets. We show that the addition of predicted backbone conformations to SVM classifiers can improve fold recognition. Our experimental results show that the inclusion of predicted backbone conformations in our feature representation leads to higher overall accuracy compared to when using amino acid residues alone.